Affiliation - John Hopkins University
Title of Talk - Water Dynamics in Cells and Tissues
The mammalian cell surface is highly permeable to water. The cell can also actively control the water flux across the cell surface by pumping solutes (mostly ions), and thereby controlling the cell water content and the cell volume. In this talk, we will explore how the cell also uses active water fluxes to move and change cell shape. The same players in the cell volume control system are involved in driving cell movement, especially in high viscosity environments. Mathematical modeling shows that the water-driven cell movement is energetically costly, but is necessary when the hydraulic environment is viscous. Finally, we will discuss how epithelial cell layers such as the kidney tubule pump water and generate mechanical force.