Marte Julie Sætra
Affiliation - Simula Research Laboratory
Title of Talk - Computational modeling of ion concentration dynamics in brain tissue
Over the past decades, computational neuroscientists have developed ever more sophisticated and morphologically complex neuron models. Most of these models assume that the intra- and extracellular ion concentrations remain constant over the simulated period and thus do not account for concentration-dependent effects on neuronal firing properties. Of the models that do incorporate ion concentration dynamics, few account for the electrodiffusive nature of intra- and extracellular ion transport. In this talk, I will present the first multicompartmental neuron model that accounts for ion concentration dynamics in a biophysically consistent manner . I will also show how electrodiffusive modeling of neurons and glial cells can be used to explore the genesis of slow potentials in the brain .