Jasmine Foo

Jasmine Foo

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Additional Details

Affiliation - University of Minnesota

Title of Talk - Understanding the role of phenotypic switching in cancer drug resistance

Abstract

Recent findings suggest that cancer cells can acquire transient resistant phenotypes via epigenetic modifications and other non-genetic mechanisms. Although these resistant phenotypes are eventually relinquished by individual cells, they can temporarily ’save’ the tumor from extinction and enable the emergence of more permanent resistance mechanisms. These observations have generated interest in the potential of epigenetic therapies for long-term tumor control or eradication. In this talk, I will discuss some mathematical models for exploring how phenotypic switching at the single-cell level affects resistance evolution in cancer. As an example, we will explore the role of MGMT promoter methylation in driving resistance to temozolomide in glioblastoma.

 

Date And Time

Nov 10, 2020 04:00 PM to
Dec 9, 2022 05:00 PM
 

Location

Online Event
 

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