Gustavo Martínez-Mekler

Gustavo Martínez-Mekler

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Additional Details

Affiliation - Instituto de Ciencias Físicas, UNAM

Title of Talk - Fertilization Regulatory Networks

Abstract

Fertilization is one of the fundamental processes of living systems. Here I will address marine external fertilization and comment on recent work on mammals. I will show experiments that substantiate that sea urchin sperms exhibit chemotaxis as they swim towards the ovum. They are guided by flagellum internal [Ca2+] concentration fluctuations triggered by the binding of chemicals from the oocyte surroundings. Based on experiment, I present a family of logical regulatory networks for the [Ca2+] fluctuation signaling-pathway that reproduce previously observed electrophysiological behaviors and provide predictions, which have been confirmed with new experiments. These studies give insight on the operation of drugs that control sperm navigation. In this systems biology approach, global properties of the [Ca2+] discrete regulatory network dynamics such as

 

Date And Time

Sep 27, 2019 04:00 PM to
Dec 9, 2022 05:00 PM
 

Location

Online Event
 

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