Yuan-Nan Young

Yuan-Nan Young

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Additional Details

Affiliation - New Jersey Institute of Technology

Title of Talk - A coarse-grained, stoichiometric model for centrosome and spindle dynamics

Event Link - https://upenn.zoom.us/j/99792332298?pwd=R1JXYmh2aGI1OUhuUzg5VFhuU0M0Zz09

Abstract

Centrosome dynamics is essential in mitosis. In eukaryotic cells, the mitotic spindle forms during cell division and ultimately separates the chromosomes into the daughter cells. The position and orientation of the division plane, which is of fundamental importance for proper growth and development, are regulated by the spindle’s position and orientation. Experiment has shown that pulling forces upon centrosomes from cortically anchored motor proteins drive spindle positioning and dynamics in cells. Here, we developed a coarse-grained model of the spindle, which accounts for the dynamics of microtubules nucleating from centrosomes and their interactions with motor proteins localized on the cell cortex. Our model quantitatively explains observed spindle dynamics in C. elegans embryos, such as elongation, asymmetric positioning, and oscillation. It also quantitatively predicts the scaling of these traits with cell size. This is a collaboration with Reza Farhadifar and Michael J. Shelley at the Center for Computational Biology, Flatiron Institute.

 

Date And Time

Oct 16, 2023 04:00 PM
Apr 17, 2024
 

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