Marino Arroyo

Marino Arroyo

by
5 5 people viewed this event.

Additional Details

Affiliation - U. Politecnica de Catalunya

Title of Talk - Cytoskeletal dynamics and their active self-organization within cells and in cell monolayers

Event Link - https://upenn.zoom.us/j/99792332298?pwd=R1JXYmh2aGI1OUhuUzg5VFhuU0M0Zz09

Abstract

The actin cytoskeleton controls many cellular functions, including shape, mechanical properties, or motility. It is remarkably adaptable and multifunctional. It often organizes into nematic bundles such as contractile rings or stress fibers. However, how a uniform and isotropic actin gel self-organizes into dense nematic bundles is not understood. I will describe our unpublished research about self-organization and polymorphism using an active gel model accounting for nematic order. Combining linear stability analysis and nonlinear finite element simulations, we establish the conditions for nematic bundle formation and how active gel parameters control the architecture, orientation, connectivity and dynamics of self-organized patterns of nematic bundles. I will discuss the connection between our active gel model and discrete network models, as well as the interaction between active nematic structures and cell shape. Finally, I will discuss how cytoskeletal dynamics within cells give rise to emergent mechanical behaviors in cell monolayers.

 

Date And Time

Jan 31, 2023 10:00 AM
Jan 29, 2023
 

Location

Online Event

Share With Friends

0
0
image
https://mathbio.sas.upenn.edu/wp-content/themes/maple/
https://mathbio.sas.upenn.edu/
#084550
style1
paged
Loading posts...
/code/
#
on
none
loading
#
Sort Gallery
on
yes
yes
off
on
off