Anna Nelson

Anna Nelson

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Additional Details

Affiliation - Duke University

Title of Talk - Mathematical models of polymerization in physiology

Event Link - https://upenn.zoom.us/j/99792332298?pwd=R1JXYmh2aGI1OUhuUzg5VFhuU0M0Zz09

Abstract

Polymerization, or aggregation, is essential for many physiological systems. For example, the emergence of a fibrin polymer mesh during the formation of a blood clot is required for a stable clot and long-term, sustained intracellular transport in neurons rely on persistent yet dynamic polymers that comprise the microtubule cytoskeleton. In the first part of the talk, I will discuss a kinetic polymerization model that represents the formation of a fibrin polymer mesh with interactions with its precursor molecule, fibrinogen. With this model, we investigate how fibrin-fibrinogen interactions can impact gel structure (such as concentration of branch points) and gel time. In the second part, I will introduce a stochastic mathematical model of individual microtubule growth and catastrophe in the dendrite of a neuron. Using parameters informed by experimental data, we explore what mechanisms could control the equilibrium microtubule length and validate these mechanisms using fluorescence microscopy data.

 

Date And Time

Oct 23, 2023 04:00 PM
Jul 15, 2024
 

Location

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