About Program Output

 

The volatility server produces output in tab-delimited format.
Information for each gene is reported on a separate line. For each gene,
the following data are reported:

- Gene name (obtained from FASTA file)
- Gene length (in residues)
- Observed volatility (per residue)
- Expected volatility
- Variance in volatility
- Volatility P-value

The expected volatility and variance in volatility of each gene is
obtained, controlling for its amino acid sequence, by using the synonymous
codon usage observed for all genes in the FASTA file, as described in
Supplementary Methods [pdf]. P-values near zero indicate significantly
elevated volatility; P-values near one indicate significantly depressed
volatility.